Synthesizing Bis(beta-iminoenolate)copper(II) Complexes and Exploring Substitution Dependent Green Catalytic Application for Azide-Alkyne Cycloaddition Reaction

摘要

abstract_textpBis(beta-iminoenolate)copper(II) complexes with different substituents (3 a-c)have been prepared and explored the catalytic activity for azide-alkyne cycloaddition reaction in environmentally benign condition. Copper complexes showed highly efficient catalytic activity and produced regioselective product of 1,4-disubstituted-1,2,3-triazoles in one-pot three component reaction between benzyl chloride, sodium azide and alkynes at room temperature in water medium. The structure-activity comparison revealed that copper complex with electron withdrawing fluoro substituent (3 c) exhibited comparatively higher catalytic activity in azide-alkyne cycloaddition reactions and produced up to 98 of yield with 12.5 mol of the catalyst without addition of any other reagent./p/abstract_text