13th CROI surprise: Antiretrovirals are good for you

摘要

With a flourish of studies on structured treatment interruptions (STIs) and the cardiovascular complications of HIV infection and its therapies, the 13th Conference on Retroviruses and Opportunistic Infections (CROI) may prove a turning point in the management of this pernicious disease. And the point returned to may be one set 10 years ago, suggested antiretroviral maven John Mellors (University of Pittsburgh). While other CROIsters harked back to the discovery of AIDS a quarter century ago or the 10th birthday of triple therapy, Mellors pointed to a single study-AIDS Clinical Trials Group (ACTG) protocol 320, the randomized trial that ratified the life-saving advantage of three antiretrovirals over two.