Synthesis and Cytotoxic Activity of Tetrazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones

摘要

Tetrazole-containing 1,5,6,7-tetrahydro-4H-indazol-4-ones were synthesized by condensation of 2-(tetrazolylacetyl)cyclohexane-1,3-diones with phenyl- or 4-fluorophenylhydrazines in ethanol at room temperature. Structure of the synthesized compounds were confirmed by H-1, C-13, F-19 NMR spectroscopy methods. Cytotoxic activity of the series of obtained compounds was investigated in vitro against human laryngeal cancer cells Hep2.