Green synthesis of substituted 1,8-naphthyridin-thiazole scaffolds, molecular docking studies and biological evaluation

摘要

Eco-friendly construction of N-(5-(2-methyl-1,8-naphthyridine)-thiazole-benzamide and 5-(2-methyl-1,8-naphthyridine)-N-(3-aryl-1,8-naphthyridine-thiazole-2-amine derivatives under microwave method afforded good yields in short reaction time with maximum selectivity compared with conventional method in the presence of triethylamine and, Pd(PPh3)(4). This route can assimilate the concept of green chemistry because reaction process is very squatter reaction time and enhanced energy efficiency. Synthesized molecules are tested for their antimicrobial activity; among them, 7e and 7b compounds have shown good results and molecular modeling evaluation has been done by considering docking scores, hydrogen bond interactions, affinity, and the short distance between ligand and receptor. In silico studies also good complimented for these results.