ADGB variants cause asthenozoospermia and male infertility

摘要

Abstract Asthenozoospermia is one of the main factors leading to male infertility, but the genetic mechanisms have not been fully elucidated. Variants in the androglobin (ADGB) gene were identified in an infertile male characterized by asthenozoospermia. The variants disrupted the binding of ADGB to calmodulin. Adgb–/– male mice were infertile due to reduced sperm concentration (