5-Aza-2 '-deoxycytidine may enhance the frequency of T regulatory cells from CD4(+) naive T cells isolated from the peripheral blood of patients with chronic HBV infection

摘要

Objectives: Methylation pattern of gene modification is essential for the differentiation of T regulatory cells (Tregs) and 5-Aza-2MODIFIER LETTER PRIME-deoxycytidine is a common inhibitor of methylation. This study aimed to investigate the potential effects of Treg polarizing conditions and 5-Aza-2MODIFIER LETTER PRIME-deoxycytidine treatment in the differentiation of naive T cells during chronic hepatitis B virus (HBV) infection.