A Facile L-Proline Catalyzed One-Pot Synthesis of Xanthene and Acridine Based Quinolones via Knoevenagel Condensation Reaction

摘要

A highly efficient, three-component one-pot and L-proline catalyzed Knoevenagel condensation reaction of substituted-2-phenoxyquinoline-3-carbaldehyde, 1,3-cyclohexanedione/dimedone or ammonium acetate is described. These reactions afford unexpected products of xanthene and acridine based quinolones in ethanol with good yields. All these isolated products are characterised by spectroscopic and analytical data.