Integrated Microsystem Toward High-Throughput Automated Green Synthesis and Raman Enhancement Performance Screening of Noble-Metal@Cu-MOF

摘要

“Green Synthesis” has been broadly applied in drug synthesis and nanomaterialpreparation. The integration of automated micro-synthesis andhigh-throughput screening systems is a key way to achieve the goal of greenmanufacturing. Here, a one-click green synthesis platform is designed thatintegrates droplets arrays-based micro-synthesis for Raman enhancementperformance high-throughput screening of MNPs@Cu-MOF (AuNPs@,AgNPs@, PtNPs@Cu-MOF) under room temperature and normal pressure.The fully integrated ultrasound units can achieve rapid multi-componentmixing in the droplet array systems, and significantly accelerate materialsgrowth as well as enhance encapsulation of noble metal nanoparticles intoCu-MOF structures. Based on such integrated systems, structures with highRaman enhancement performance can be high-throughput evaluation andeasily screened out. The results indicated that the AgNPs@Cu-MOF exhibitedthe best Raman enhancement performance, which is ≈8 times higherthan pure AgNPs. Such a green and integrated platform provides a way forautomated multi-type composites fabrication, which can be expanded tomultiple fields in the future via combined robotic platforms and artificial intelligencetechnology.