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Durability of left bundle branch area pacing

机译:左束支区起搏的耐久性

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Abstract Background Left bundle branch area pacing (LBBAP) is a form of conduction system pacing. Long‐term data on the safety and performance of LBBAP 1 year postdevice implantation has not been well described. Methods and Results Sixty‐five patients (49 females) who received LBBAP for bradycardia indications using the SelectSecure 3830 lead (Medtronic) were retrospectively evaluated. Clinical variables were examined. Lead parameters were obtained at implant and during regular follow‐up. Mean age of patients was 75.7?±?10.1 years with left ventricular ejection fraction 59.8?±?10.4. Indications for pacing were atrioventricular block 55, sinus node dysfunction 19, tachy‐brady syndrome 15, atrioventricular node ablation 8, and bail out cardiac resynchronization therapy 3. Mean baseline QRS measured 120?±?38?ms, paced QRS duration was 138?±?22ms. Paced QRS narrowed by 24?ms in those with pre‐existing left bundle branch block (BBB), increased by 1?ms in those with pre‐existing right BBB, and increased by 42?ms in those with no BBB. LBBAP threshold at implant was 0.521?±?0.153?V at 0.4?ms, and increased to 0.654?±?0.186?V at 3 months (+26), 0.707?±?0.186?V at 6 months (+36), and 0.772?±?0.220?V at 12 months (+48). Patients with left BBB showed the maximum benefit with QRS narrowing 24?ms. Pacing impedance remained unchanged with no procedure‐related complications. Conclusion LBBAP is a durable form of conduction system pacing with pacing thresholds remaining relatively stable over 12 months post device implantation. Patients with left BBB display the narrowest paced QRS.
机译:摘要 背景 左束支区起搏(LBBAP)是传导系统起搏的一种形式。关于设备植入后 1 年 LBBAP 安全性和性能的长期数据尚未得到很好的描述。方法和结果 回顾性评估了65例使用SelectSecure 3830导联(美敦力)接受LBBAP治疗心动过缓适应症的患者(49%为女性)。检查临床变量。在植入时和定期随访期间获得铅参数。患者平均年龄为75.7岁±10.1岁,左心室射血分数为59.8±10.4%。起搏指征为房室传导阻滞 55%、窦房结功能障碍 19%、快速缓缓综合征 15%、房室结消融术 8% 和心脏再同步治疗 3%。平均基线 QRS 测量值为 120?±?38?ms,起搏 QRS 持续时间为 138?±?22ms。在已有左束支传导阻滞 (BBB) 的患者中,起搏 QRS 变窄了 24 毫秒,在已有右束支传导阻滞 (BBB) 的患者中增加了 1 毫秒,在无血脑屏障的患者中增加了 42 毫秒。植入时的LBBAP阈值为0.521?±0.153?V在0.4?ms时,增加到0.654?±?0.186?3 个月时 V (+26%), 0.707?±?0.186?6 个月时的 V (+36%),以及 0.772?±?0.220?12 个月时为 V (+48%)。左侧血脑屏障患者在 QRS 变窄 24?ms 时显示出最大的获益。起搏阻抗保持不变,没有与手术相关的并发症。结论 LBBAP是一种持久的传导系统起搏形式,起搏阈值在装置植入后12个月内保持相对稳定。左血脑屏障患者的 QRS 速度最窄。

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