As an environmental endocrine disruptor, estrogen has anendocrine‐disrupting effect on the human body and affectshuman health. This study uses the estrogen receptor relativebinding affinity to characterize the biological activity of estrogensand calculates the three‐dimensional quantitative structure–activity relationship of estrogen to obtain comparative molecularfield analysis (r~2 = 0.721, r~2 = 0.925) and comparative molecularsimilarity indices analysis (r~2 = 0.824, r~2 = 0.961) models. Estrogenconcentration detection and estrogen effect evaluation werecarried out on pig feed and pork in various regions of China.Detection rates of phytoestrogens in pig feed and pork are 75and 92, respectively. The detection rate of natural estrogens inpig feed and pork is 33. Synthetic estrogens were not detectedin pig feed, and the detection rate of synthetic estrogens in porkis 33. The bioconcentration factor of phytoestrogens from pigfeed to pork is 0.27–8.2. An estrogen risk assessment has beenconducted on pork. The results show that although the risk indexindicates that estrogens in pork are relatively safe, phytoestrogenssuch as carvacrol, coumarin, and beta‐sitosterol haverelatively high estrogenic effects.
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