Annulation of m-Substituted Aromatic Ketones with Diphenylacetylene Catalyzed by Ruthenium: A Reliable Route to Substituted Naphthalene Derivatives

摘要

The Ru-catalyzed annulation reaction of m-substituted aromatic ketones with diphenylacetylene to prepare polysubstituted naphthalene derivatives was reported. m-Substituted aromatic ketones have two different ortho C-H bonds; the experimental results and theoretical calculation both illustrate that m-substituted aromatic ketones use less hindered C-H bond to participate in the cyclization. The method has the advantages of forming two new carbon-carbon bonds in one single step, wide substrates tolerance, and mild reaction conditions.