Construction of antifouling and antibacterial polyhexamethylguanidine/chondroitin sulfate coating on polyurethane surface based on polydopamine rapid deposition

摘要

Implanted medical devices are widely used in clinic for disease treatment, but they generally suffer from the bio-fouling problem which leads to the reduction of service life and loss of therapeutic effects. Herein, an eco-friendly method based on polydopamine (PDA) fast deposition is developed to construct anti-fouling and antibacterial surface on polyurethane (PU). The self-adhesive layer of PDA contributes to the formation of a platform with active sites for further antibacterial and hydrophilic modification. Polyhexamethylguanidine (PHMG) as antibacterial ingredient and chondroitin sulfate (CS) as hydrophilic component covalently bind on PDA platform, which successively helps to form PU-PDA/PHMG/CS. The resultant surface demonstrates the excellent property of anti-protein adsorption (96.8), anti-bacterial ability (99.9), and cell compatibility (95.0), which would have great potential for medical application.