Synthesis and Biological Evaluation of Novel 1,3,4 -Thiadiazole Heterocyclic Derivatives as Novel Anti-Microbial Agents

摘要

Heterocyclic compounds are commonly used Scaffolds on which pharmacophores are arranged to provide potent and selective drugs. This is especially true for five-membered ring heterocyclic compounds, which serve as the core components of many substances that possess a wide range of interesting biological activities. New series of 1,3,4- Thiadiazole derivatives were synthesized From Benzyl Isocynate and Acid hydrazide, by using P-TsCl in NMP, The Novel Derivatives have been screened for their antimicrobial activity.