Dose adjustments of antimicrobials in patients withhepatic impairment

摘要

After reading this article, you should be able to: Understand the importance of appropriate dosing in relation to antimicrobialresistance, patient safety and treatment outcomes; Define the pharmacokinetic/pharmacodynamic (PK/PD) profile of commonantimicrobials; Understand the changes in PK/PD in patients with hepatic impairment; Recognise the need for dose reductions of antimicrobials in patients with hepaticimpairment.