Synthesis of 2,3-dihydrofurans via Lewis acid-Catalyzed 4+1 Cycloaddition of Enynones with Sulfoxonium Ylides in Ionic Liquids: A Mild and Green Platform

摘要

The zinc-catalyzed 4+1 cycloadddition followed by intramolecular insertion reaction between enynones and sulfoxonium ylides for the synthesis of multisubstituted 2,3-dihydrofurans in ionic liquids is described. This highly efficient and step-economical reaction displays excellent functional group compatibility and stereoselectivity. The reaction media colud maintain high reaction activity even after six cycles.