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>A silver-catalyzed stereoselective domino cycloisomerization-vinylogous aldol reaction of ortho-alkynylbenzaldehydes with 3-alkylidene oxindoles: an entry to functionalized isochromenes
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A silver-catalyzed stereoselective domino cycloisomerization-vinylogous aldol reaction of ortho-alkynylbenzaldehydes with 3-alkylidene oxindoles: an entry to functionalized isochromenes
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机译:A silver-catalyzed stereoselective domino cycloisomerization-vinylogous aldol reaction of ortho-alkynylbenzaldehydes with 3-alkylidene oxindoles: an entry to functionalized isochromenes
A silver tetrafluoroborate catalyzed domino cycloisomerization-vinylogous aldol addition sequence on a multifunctional substrate such as ortho-alkynylbenzaldehydes yielding functionalized 1H-isochromenes in a single step with high yield and excellent diastereoselectivity (>19: 1) is described. The reaction was well tolerated by alkyl, aryl, and unsubstituted alkynylbenzaldehydes, and furnished selective 6-endo-dig adducts exclusively without loss in the regio- as well as diastereoselectivity.
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