Alantolactone Suppresses Inflammation and Oxidative Stress in Doxorubicin Induced H9c2 Cells

摘要

Use of alantolactone in traditional Chinese medicine has been reported in a wide variety of diseases. To explore the role of alantolactone in chronic heart failure, its effect on doxorubicin treated H9c2 cells as a model was examined. The results of our studies show doxorubicin treatment decreased cell viability, enabled induction of secretion of proinflammatory cytokines, increased expression of malondialdehyde and decreased expression of superoxide dismutase, and enabled downregulation of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 pathways. Furthermore, all the reported effects of doxorubicin were reversed by alantolactone. In conclusion, alantolactone exhibits anti-inflammatory and antioxidative effects on doxorubicin treated H9c2 cells through activation of nuclear factor erythroid 2-related factor 2/heme oxygenase-1 and inactivation of nuclear factor-kappa B pathway. Therefore, alantolactone might be a potential agent for the prevention of doxorubicin induced chronic heart failure.