Efficient synthesis of novel chromeno2,3-d1,3,4thiadiazolo3,2-apyrimidine derivatives via three-component reaction using acidic ionic liquid catalysts in ethylene glycol

摘要

A facile and efficient greener synthesis of a novel four-fused ring heterocyclic system via three-component reactions of 1,3,4thiadiazolo3,2-apyrimidin-5-one, aromatic aldehyde, and 1,3-cyclohexanediones, in the presence of 1-(4-sulfonic acid)butyl-3-methylimidazolium hydrogen sulfate, has been presented. The synthesized compounds were characterized by mass spectrometry, IR, H-1-NMR, C-13-NMR, and elemental analysis. The remarkable features of this method are using acidic ionic liquid catalyst, green solvent media, short reaction time, good yields, and simple purification techniques. GRAPHICS