Determining Serum Haptoglobin and Proinflammatory Cytokines Concentration in the Calves Clinically Diagnosed with Pneumonitis, Pneumoenteritis and Enteritis

摘要

Background: This study aims to determine the concentration of serum haptoglobin (Hp), interleukin 1 (IL-1 beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in cases of Pneumonia, Pneumoenteritis and Enteritis. Methods: 60 calves were subjected to the study and they were divided into four groups. The study group consisted of the claves diagnosed with clinical pneumonia (Group P; n=15), pneumoenteritis (Group PE; n=15) and enteritis (Group E; n=15) while the control group included the healthy calves (Group C; n=15). The measurements of the concentration of serum haptoglobin (Hp), interleukin 1 (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), Total protein (TP) and Albumin (ALB) were made by using commercial kits. Conclusion: In all infection groups (P, PE ve E), Haptoglobin concentration, serum cytokine (IL-1 beta, IL-6 and TNF-alpha) and Albumin values were found to have been higher than the control group (p <= 0.005). However, there was no difference in total protein. In the light of these findings, it is suggested that routine controls for Haptoglobin and cytokine (IL-1 beta, IL-6 and TNF-alpha) concentrations would be rewarding to determine the severity of the infection, to choose the suitable treatment and to detect subclinical infections in veterinary medicine.