Low-dose steroids almost double risk of cardiovascular disease

摘要

Patients treated with glucocorticoids, even at doses as low as 5mg daily, are at increased risk of cardiovascular disease (CVD), research in PLOS Medicine has suggested (3 December 2020) . Scientists examined data collected between 1998 and 2017 for 87,794 patients in the UK with at least one of six common immune-mediated inflammatory diseases. They found that the overall risk of CVD almost doubled in patients taking less than 5mg prednisolone per day, compared with periods of non-glucocorticoid use (hazard ratio HR 1.74, 95 confidence interval CI 1.64–1.84). 1