Dissociation between syncytia formation and HIV spreading. Suppression of syncytia formation does not necessarily reflect inhibition of HIV infection

摘要

AbstractIn this study, we have observed that a disociation may occurin vitrobetween syncytia formation and HIV spreading‐Efficient HIV spreading and virus replication occurred either in HIV‐infected LFA‐1+lymphocytes treated with anti‐LFA‐1 mAb or in HIV‐infected lymphocytes genetically deficient in LFa‐1, despite the fact that syncytia formation was completely suppressed. Therefore, these results indicate that syncytia formation cannot be used as the sole parameter to evaluate the spread o