Detection of polymorphisms in the promoters of matrix metalloproteinases 2 and 9 genes in breast cancer in South Brazil: preliminary results.

摘要

Recently, studies have been focused on single nucleotide polymorphisms (SNPs) in matrix metalloproteinases 2 (MMP-2 C-1306T) and 9 (MMP-9 C4562T) promoter regions and its role as a risk factor for cancer development. Concerning to breast cancer and MMP-2 C-1306 T, two studies were reported so far. Zhou et al., in China, showed that T alelle carries have a diminished risk of cancer development . However, no association was detected among genotypes, TNM stage and estrogen receptor (ER) status , On the other hand, Grieu et al., in a case-series of Caucasian individuals, in Australia, showed significant association between TT genotype and small and ER negative tumors . In the same sample TT homozygous patients with ER negative tumors had poor survival rates (P < 0.001) .