Duloxetine and serotonin syndrome

摘要

Duloxetine is a serotonin and noradrenaline reuptake inhibitor indicated for the treatment of major depressive disorder, generalised anxiety disorder and diabetic peripheral neuropathic pain.Serotonin syndrome is a known risk associated with duloxetine therapy and is listed as a precaution in the Product Information (PI).To reduce the risk of serotonin syndrome, duloxetine should be used with caution with other serotohergic drugs, including selective serotonin reuptake inhibitors, tricyclic antidepressants, opioids, tryptophan and St John's wort.