Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis

摘要

Abstract Background Among eye movements in amyotrophic lateral sclerosis (ALS), we identified the characteristics of square-wave jerks (SWJs) seen during times without visual fixation (VF) and analyzed their relationships with clinical parameters.Materials and Methods Clinical symptoms were evaluated and eye movements were tested using electronystagmography in 15 patients with ALS (10 men, 5 women; mean age, 66.9?±?10.5?years). SWJs with and without VF were recorded, and their characteristics were identified. Relationships between each SWJ parameter and clinical symptoms were evaluated. Results were compared with eye movement data from 18 healthy individuals.Results The frequency of SWJs without VF was significantly higher in the ALS group than in the healthy group (P?