Ca(IO3)(2) nanoparticles: fabrication and application as an eco-friendly and recyclable catalyst for the green synthesis of quinoxalines, pyridopyrazines, and 2,3-dicyano pyrazines

摘要

In this paper, calcium iodate nanoparticles were first synthesized by the modified reaction of Ca(NO3)(2) and KIO3 in an aqueous medium under ultrasonic irradiation. The structure of nanocatalyst was then characterized by FT-IR, FESEM, EDX, XRD, and BET techniques. Afterward, the fabricated Ca(IO3)(2) was applied as a nanocatalyst in the facile synthesis of heterocycles including quinoxalines, 5,6-dicyano pyrazines, and pyrido2,3-bpyrazines. For this purpose, the feasibility of the reaction in the presence of different catalyst amounts, solvents, and temperatures was first investigated. Next, the target compounds were obtained by the condensation reaction of aryl-1,2-diamines or 2,3-diaminomaleonitrile with 1,2-diketones in the presence of a catalytic amount of Ca(IO3)(2) in ethanol or acetic acid solvents at ambient temperature in good to excellent yields. One of the salient advantages of this work is the synthesis of calcium iodate nanoparticles by chemical precipitation method and its application as a heterogeneous nanocatalyst for the first time in the synthesis of organic compounds. The other important benefits of this process are the use of an inexpensive, safe, stable and recyclable catalyst, high product yields, short reaction times, and easy isolation of the product in pure form.