Abstract As a water‐soluble macromolecule polysaccharide, xanthan gum (XG) has several biological activities, such as antitumor, antiviral, and immunomodulatory function. However, the effect of XG on the proliferation and cytotoxicity of cytokines induced killer (CIK) cells is rarely studied. In this study, the effect of XG on CIK cells derived from peripheral blood was investigated by analyzing the expansion fold of total cells, phenotype, cytotoxicity, degranulation, and apoptosis in serum‐free medium. The results showed that the expansion fold of total cells with 100?μg/ml XG which molecule weight is 2.95?×?106?Da reached 4534.0 folds, significantly higher than that without XG (1299.0 folds, p?
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