A Practical Synthesis of 2-Arylimino-2H-Chromenes via Biocatalytic System in Water

摘要

A metal-free, straightforward, non-hazardous reagent-added, one-pot approach for the efficient synthesis of 2-arylimino-2H-chromenes with high yields was developed for the first time in this report through the coupling of salicylaldehydes with beta-ketothioamides, which was catalyzed by lipase in water. This green strategy provides an efficient method to obtain various 2-arylimino-2H-chromenes and enriches the practical application of biocatalysis.