Bacterial Transcription Continues to Surprise: Activation by Alarmone-Mediated sigma-Factor Tethering

摘要

Travis et al. (2020) reveal how Francisella tularensis uses stress-induced ppGpp to activate its virulent pathogenesis program by tethering an alpha CTD-DNA organizer (PigR) to a sigma-organizing heterodimer (MglA-SspA), highlighting the remarkable diversity of transcriptional mechanisms in under-studied bacteria.