Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart

JaberN.; DouZ.; LinR.Z.; ZhangJ.; ZongW.-X.

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Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart

机译：哺乳动物PIK3C3 / VPS34：肝脏和心脏自噬过程的关键

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PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.

机译：PIK3C3 / Vps34是III类PtdIns3K，从酵母到哺乳动物在进化上都是保守的。通过使用药理抑制剂和研究其结合伴侣，已表明其在哺乳动物自噬中的重要作用。但是，PIK3C3在哺乳动物中的确切作用尚不清楚。使用允许组织特异性删除PIK3C3的小鼠品系，我们已经描述了PIK3C3在调节自噬以及肝脏和心脏功能中的重要作用。

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《Autophagy》 |2012年第4期|共2页
作者
JaberN.; DouZ.; LinR.Z.; ZhangJ.; ZongW.-X.;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
Autophagy; Cancer; Endocytosis; Heart; Liver; PIK3C3; PtdIns3K; PtdIns3P; VPS34;

机译：自噬;癌症;内吞作用;心脏;肝脏;PIK3C3;PtdIns3K;PtdIns3P;VPS34;

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1. Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart [J] . JaberN., DouZ., LinR.Z., Autophagy . 2012,第4期

机译：哺乳动物PIK3C3 / VPS34：肝脏和心脏自噬过程的关键
2. Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway [J] . Xiang Zhou, Liangli Wang, Hiroshi Hasegawa, Proceedings of the National Academy of Sciences of the United States of America . 2010,第20期

机译：感觉神经元中PIK3C3 / Vps34的缺失通过破坏内体而不是自噬途径而引起快速的神经变性
3. PIK3C3/VPS34 links T-cell autophagy to autoimmunity [J] . Guan Yang, Luc Van Kaer Cell death & disease. . 2020,第5期

机译：Pik3C3 / VPS34将T-Cell自噬链接到AutoImmunity
4. Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function [C] . Nadia Jaber, Wei-Xing Zong Inositol Phospholipid Signaling in Physiology and Disease (Conference) . 2013

机译：III类PI3K VPS34：自噬，内吞作用和心脏和肝功能中的基本作用
5. Physiological role of Vps34 phosphatidylinositol 3-kinase in mammalian cells. [D] . Johnson, Erin E. 2005

机译：Vps34磷脂酰肌醇3-激酶在哺乳动物细胞中的生理作用。
6. Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function: PIK3C3/VPS34 in T cell metabolism and function [O] . Guan Yang, Wenqiang Song, J. Luke Postoak, 2021

机译：与自噬相关的蛋白Pik3C3 / VPS34控制T细胞代谢和功能：PIK3C3 / VPS34在T细胞代谢和功能中
7. ABSTRACT Various body parts or organs can be analysed to identify the different diseases in the human body. Fingernail analysis is one of the ways to identify disease in the human body. Nails are the body part which are farthest from the heart and therefore receive oxygen at last. As a result the nails are the first who show the symptoms of a disease in the human body. Fingernails can be easily captured for diagnosis and there are no heavy equipment or no specific conditions required to use nail image for disease diagnosis, like in other tests and scanning processes. Human nails deliver beneficial information about complaints or any nutritive imbalances in the human body depending upon their shape, texture and colour. In human beings, numerous systemic and skin diseases can be easily analyzed through careful examination of nails of both the limbs. A lot of nail illnesses have been found to be primary signs of numerous underlying systemic illnesses. The colour, texture or shape changes in nails are signs of many diseases mainly affecting nails. Considering all these properties of nails a system is proposed that uses digital image processing (DIP) methods for identifying such changes in the human nail to get more precise results and predict numerous diseases effortlessly. With the emerging Internet of Things (IOT) concept the generated report is made available remotely, this will help users to reduce transportation efforts. As the system has to deal with large and private data, the security of data must be ensured. To keep the data confidential, the Blockchain concept which is one of the most emerging concepts in the field of data management is used. The paper contains the implementation of the digital image processing for feature extraction of nail images, usage of IOT (ThingSpeak cloud) for data storage and implementation of Blockchain to keep the system secured and theft free. KEY WORDS: Int ernet of thin gs (IOT), Image proc essin g, Thin gSpeak, RG B vavalues, Mean pi xel vavalues, Bloc kchain , Hash key. Disease Diagnostic System: Abnormalities in Human Nail [O] . Pranav S. Wazarkar 2020

机译：摘要的各个身体部位或器官可被分析以识别在人体内的不同的疾病。指甲分析来识别人体疾病的方法之一。指甲是身体一部分是离心脏最远，因此在最后接受氧气。作为结果，指甲是第一谁表现出人体疾病的症状。指甲可以容易地捕获用于诊断和没有重装或需要使用指甲图像用于疾病诊断，比如在其他测试和扫描过程没有特定的条件。人的指甲提供有关投诉或取决于它们的形状，纹理和色彩在人体内的任何营养失衡有益的信息。在人类中，许多全身性皮肤疾病是可以很容易地通过两个四肢指甲的仔细检查分析。很多指甲病已发现众多潜在系统性疾病的主要症状。在指甲的颜色，质地和形状的变化是许多疾病主要影响指甲的迹象。考虑到所有的指甲的这些性能的系统被提出，用于识别人指甲这样的变化以获得更精确的结果，并毫不费力预测许多疾病用途的数字图像处理（DIP）方法。随着物联网（IOT）的概念，新兴的互联网将生成的报告提供远程，这将帮助用户降低运输工作。由于系统必须处理大量的私人数据，数据的安全性必须得到保证。为了保持数据的机密性，使用Blockchain的概念，它是在数据管理领域的大多数新兴的概念之一。本文包含了数字图像处理的指甲图像，IOT（ThingSpeak云）的使用为数据存储和执行Blockchain的特征提取的执行，以保持固定的系统和盗窃免费。关键词：诠释薄GS（IOT），图像的ERNET PROC essin克，薄型gSpeak，RG乙vavalues，平均数PI XEL vavalues，阵营kchain，哈希密钥。疾病诊断系统：在人类指甲异常
8. Oxygen Delivery and Myocardial Function in Rabbit Hearts Perfused with Cell-FreeHemoglobin [R] . Macdonald, V. W., Winslow, R. M. 1992

机译：用无细胞血红蛋白灌注兔心脏的氧输送和心肌功能

Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart

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