Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization of norbornene and norbornadiene

摘要

A highly enantioselective Pd/Xiang-Phos-catalyzed carbohetero-functionalization of norbornene is described, giving a direct access to various chiral norbornane-fused dihydrofurans and dihydro-pyrroles. This synthetic methodology provides the first example of asymmetric carboetherification of norbornene, and also tolerates norbornadiene well.