Histopathologic and immunohistochemical findings of odontogenic jaw cysts treated by decompression technique

摘要

Context: Odontogenic cysts are among the most common lesions to affect the oral and maxillofacial region.Cysts are capable of causing significant bony disfigurement, tooth displacement and pathological fractures.Several surgical approaches exist for the management of larger cysts of the jaws. These include enucleation,marsupialization and decompression.Aims:1. Analysis of histopathologic findings in odontogenic cysts before and after decompression2. Analysis of Ki-67 expression in odontogenic jaw cysts before and after decompression.Settings and Design: Decompression technique was used for the treatment of 10 cases of odontogeniccysts in the study. Incisional biopsies of cystic lining (pretreatment) and corresponding excisionalbiopsies (posttreatment) were received for histopathologic and immunohistochemical examination.Subjects and Methods: Hematoxylin and eosin stain was used for histopathologic findings, and Ki-67 wasused for immunohistochemical findings using antibody Ki-67 in fresh tissue samples.Results: Overall, radicular cysts, dentigerous cysts, and sialo-odontogenic cyst contained fewer Ki-67 + cellsthan odontogenic keratocysts. The average scores were found to be 2.2 and 1 for before and afterdecompression, respectively. A statistically significant difference was observed between the two groups.The two-tailed P value was found to be 0.0001. The confidence interval was found to be 95%.Conclusions: The proliferative activity evaluated by Ki-67 marker was greater in predecompression epitheliallining compared to postdecompression. Our study infers that proliferative rate of the cystic epithelial liningis significantly diminished after decompression.