Fabrication of a pH-Responsive Magnetic Nanocarrier Based on Carboxymethyl Cellulose-Aminated Graphene Oxide for Loading and In-Vitro Release of Curcumin

摘要

Abstract In this study, a pH-responsive magnetic drug delivery system was prepared by?cross-linking of Cofe2O4/graphene oxide to carboxymethyl cellulose (CMC) biopolymer with adipic acid dihydrazide (ADH) and then investigated for loading and release of a poorly water-soluble anti-cancer drug, curcumin (CUR). The CoFe2O4/GO-ADH-CMC bio-nanocomposite was characterized?by FE–SEM/EDX, TEM, FT–IR, XRD, TGA, VSM, and zeta-potential techniques. The highest amount of drug loading was achieved as 23.7?mg?g–1 at 323?K, pH 6.0, and 120?mg L–1 CUR concentration. The study of adsorption isotherms revealed that the Sips model was best fitted to the equilibrium data (R2?>?0.997 and RMSE?