The human OTF1 locus which overlaps the CD3Z gene is located at 1q22→q23

摘要

The human OTF1 locus encoding the Oct-1 protein has previously been mapped to chromosome 1cen→q32 by analysis of somatic cell hybrids. We report here the regional localization of OTF1 to 1q22→q23 by fluorescence in situ hybridization. The physical linkage of the CD3Z gene to the OTF1 transcription unit also refines the location of the CD3Z locus to 1q22