Bismuth oxide modifies titanium implant for improved osteogenesis and immune regulation

摘要

Aseptic loosening often leads to orthopedic implantation failure. In this study, to improve the osteointegration of Ti orthopedic implants, bismuth oxide (Bi_2O_3) layer was magnetron sputtering coated on Ti surface. The Bi_2O_3 coating had few influence on the surface morphology and wettability of Ti. In vitro cell culture of rat bone marrow stem cells (rBMSCs) suggested that Bi_2O_3 coating showed good cytocompatibility and was favorable for its osteogenic differentiation. Furthermore, the Bi_2O_3 coating was found to induce macrophage cells (RAW264.7) polarize to anti-inflammatory phenotype, whereas inhibit its pro-inflammatory polarization. With improved osteogenesis and tissue repair immune regulation, the designed Bi_2O_3 coating is promising for orthopedic applications.