Green synthesis of isatin-based compounds

摘要

Isatin and related derivatives are synthetically versatile substrates. These compounds can form a wide range of heterocyclic structures. These characteristics make isatin and its derivatives attractive to many research groups. There are lots of review articles about these compounds, but none of them focus on green solvents. This review, with the point of green chemistry, summarizes recent reactions of isatin, especially in water and aqueous media, during the period from 2018 to 2021. We believe this gives some insight and helps to bring about new ideas for further research.