Effect of subthreshold nanosecond laser on retinal structure and function in intermediate age‐related macular degeneration

摘要

Abstract Background Subthreshold nanosecond laser (SNL) treatment has been studied as a potential intervention in intermediate age‐related macular degeneration (iAMD). This study investigated the effect of 100 SNL treatment spots on retinal structure and function. Methods A prospective single‐arm interventional pilot study. SNL treatment was delivered as 100 spots around the retinal vascular arcades of the study eye (worst visual acuity) in a single session in subjects with iAMD. Multimodal retinal imaging and dark‐adapted chromatic perimetry were performed at baseline and at 0.5, 3, 6 and 12?months post treatment. Post treatment changes in best corrected visual acuity (BCVA), retinal thickness, relative ellipsoid zone reflectivity (rEZR) and rod‐mediated functional parameters were compared to baseline. Results Twenty‐one subjects with iAMD were recruited. SNL treatment was associated with an increase in retinal thickness (p?=?0.008) and decrease in rEZR (p?