Comparison of serum cytokines between gestational diabetes mellitus and normal pregnancy women: a pilot study

摘要

Abstract Aim Gestational diabetes mellitus (GDM) is associated with a higher risk of postpartum type 2 diabetes mellitus and a series of complicates, such as adverse obstetric and perinatal outcome. We aimed to evaluate cytokines profile in women with GDM.Materials and methods Based on a 75g oral glucose tolerance testing (OGTT), the participants were divided into two groups: GDM (n=28) and normal glucose tolerance (NGT) (control group, n=20). Flow cytometry was used to assess serum cytokines. The levels of glycosylated hemoglobin (HbA1c), glucose, and high-sensitive C-reactive protein (hsCRP) were measured.Results HsCRP, interleukin (IL)-2, and IL-6 were higher in GDM group as compared with the NGT group. HsCRP and IL-6 concentrations positively correlated to Hb1Ac and OGTT. A number of cytokines (such as IL-10, IL-8, IL-12p70, INF-γ, IL-4, IL-17, and IL-10) might exhibited beneficial effects against GDM.Conclusions Our results showed that the GDM patients developed a low-grade inflammatory state and presented a disorder of cytokines . These observations suggest that dysregulation of concentrations of pro- and anti-inflammatory cytokines in pregnancy is associated with GDM development.