Two new nitrogenous compounds identified as (2S)-2-sinapoyl-4-pentenenitrile (1) and brassicalkaloid A (2) have been isolated from the seed of Brassica napus L. along with four known alkaloids (3–6). The chemical structures of the new compounds were determined by detailed analysis of spectral data including 1D and 2D NMR spectroscopy. The antineuroinflammatory activity of the isolated compounds was investigated. Brassicalkaloid A (2) and coixspirolactam C (5) were found to exhibit potent activities with IC50 values of 36.6 ± 0.04 μM and 51.0 ± 0.01 μM.
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机译：已从甘蓝型油菜 L. 种子中分离出两种新的含氮化合物，即 （2S）-2-芸酰基-4-戊烯腈 （1） 和芸苔碱 A （2） 以及四种已知的生物碱 （3–6）。通过对包括一维和二维核磁共振波谱在内的光谱数据进行详细分析，确定了新化合物的化学结构。研究了分离化合物的抗神经炎症活性。发现芸苔碱 A （2） 和 coixspirolactam C （5） 表现出有效的活性，IC50 值分别为 36.6 ± 0.04 μM 和 51.0 ± 0.01 μM。
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