Network Effects of the 15q13.3 Microdeletion on the Transcriptome and Epigenome in Human- Induced Neurons

摘要

BACKGROUND: The 15q13.3 microdeletion is associated with several neuropsychiatric disorders, including autism and schizophrenia. Previous association and functional studies have investigated the potential role of several genes within the deletion in neuronal dysfunction, but the molecular effects of the deletion as a whole remain largely unknown.