Two new chromone derivatives (1 and 2) were isolated from the twigs of Cassia auriculata. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD of 12.8 ± 2.2 and 13.0 ± 2.5 mm, respectively.
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