Prevalence of venous thromboembolism and its associations in a large racially homogenous population of sickle cell disease patients

摘要

Abstract To determine the prevalence of venous thromboembolism (VTE) among adult sickle cell disease (SCD) patients in Nigeria. Methods This was a multicentre retrospective study in which the medical records of adult SCD patients were reviewed. Information on demographics, steady‐state haemogram, clinical phenotypes, duration of follow‐up, history of VTE including risk factors and management was collected. Results Of the 509 SCD patients with a median (IQR) duration of follow‐up of 2?years, 10 (2.0%) had VTE (9 DVT and 1 PE). Their median (IQR) age was 27 (22.8–30.3) years. Identifiable risk factors for VTE included positive family history (2, 20%) surgery, splenectomy, paraplegia and cancer (1, 10% each). No risk factor was identifiable in four persons. VTE had no significant association with age and gender. VTE was significantly associated with the following events: acute chest syndrome [p?=?.002, odds ratio (OR) 8, 95% CI 2.2–28.9], osteonecrosis [p?=?.012, OR 5.24, 95% CI, 1.45–18.91] and vaso‐occlusive crisis [p?=?.035]. Also significantly associated with VTE were pulmonary hypertension [p?=?.001, OR 23.3, 95%CI 5.18–105.06] and stroke [p?=?.032, OR 9.35, 95%CI 0.87–53.25]. Conclusion The prevalence of VTE among SCD patients in Nigeria is low. It is significantly associated with vaso‐occlusive crisis, pulmonary hypertension and stroke.