Enteric glial cells mediate gut immunity and repair

摘要

In the gut, coordinated cell interactions regulate tissue repair and immunity. How enteric glial cells (EGCs) mediate these processes remained elusive. In a recent paper, Progatzky et al. demonstrate that EGCs interact with immune and mesothelial cells under homeostasis and helminth infection, revealing an indispensable role of an interferon-gamma (IFN gamma)-EGC-CXCL10 axis in tissue repair.