Functionalization of halloysite nanotubes via grafting of polyhedral oligomeric silsesquioxane (POSS) nanoparticles for paclitaxel drug delivery

摘要

To get high loading capacity and sustained release behavior of paclitaxel (PTX) anticancer drug, halloysite (Hal) nanotubes were functionalized with octa-aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt nanoparticles (OAPOSS NPs) as novel drug delivery system. The novel nanocarrier, OAPOSS-g-Hal, was char-acterized using different methods. The in-vitro release experiments showed that PTX outflow rate from OAPOSS-g-Hal at pH 5.2 was higher than pH 7.4. The release kinetics of PTX were studied using Higuchi and Korsmeyer-Peppas models. Moreover, the cytotoxicity effect of the samples against cancer cells was studied using thiazolyl blue tetrazolium bromide assay (MTT). All the above results showed that OAPOSS-g-Hal had a great potential to be a novel drug delivery system.