pH-responsive self-healing of chemically modified tragacanth gum hydrogels as antibiotic release system

摘要

Herein, we reported pH-responsive self-healing hydrogels from cross-linked tragacanth gum (TG) as a controlled antibiotic release system using varying gum concentrations at changing temperatures using both glutaraldehyde and citric acid. TG-HGs can sustain multiple cycles of healing and separation by relatively maintaining their mechanical and healing properties. Cefazolin (Cf) loaded TG-HGs showed a respectively slow drug release over 8-24 h depend on the TG concentration. Prepared cf-loaded hydrogels showed excellent antibacterial activity against both gram-negative and gram-positive bacterium, and resulted in high mortality (99.3%) on S. aureus with a robust inhibition of biofilm formation.