Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

摘要

Growing concern about photothermal tumor therapy (PTT) as a promisingalternative to conventional liver cancer treatment, which is a treatmentstrategy that utilizes near-infrared (NIR) light-induced photothermal agents(PTAs) to yield photothermal effects to localize thermal damage for tumors.Herein, given the gap between experimental research and clinical application,this review seeks to timely summarize and highlight the recent progress ofPTAs used for photothermal treatment of liver cancer in vivo and in vitro inthe last five-year. The implications of various PTAs on the multifunctionalphotothermal conversion capability, the structure-performance correlations ofPTT, together with the evaluation of their potential in application aresystematically dissected to further dig out what the buried mechanism is.Besides, higher requirements are put forward for the discrepancies andcrucial issues faced by different PTAs in PTT with related medical technicalobstacles being conquered, which lays a solid theoretical foundation for themedical field of oncology treatment as a whole, especially liver cancer. Finally,it is expected that this review can present valuable guidance for the design ofefficient, photostability, and biosafety-aware PTAs for anticancer therapy whilestepping into the fast traffic lane for the conversion from bench to bedside inthe foreseeable future.