Photocatalyzed gem-Difluoroallylation of Tertiary Amines with alpha-Trifluoromethyl Alkenes

摘要

The gem-difluoroalkene moiety has attracted considerable attention from the synthetic chemistry community due to its outstanding performance in the drug design and development. By employing 4-CzIPN as photocatalyst, a metal-free synthetic method for gem-difluoroalkenes is developed under blue LED irradiation. A wide range of tertiary amines and alpha-trifluoromethyl alkenes are applicable in the present gem-difluoroallylation and successfully transformed into the gem-difluoroalkenes in good yields.