In 2019 the National Science Foundation in the United States began operation of its Frontera supercomputer at the Texas Advanced Computing Center, debuting at number 5 on the TOP500 list. Unlike more general purpose supercomputers, Frontera was designed for the focused community of users doing computational science at the largest scale. This special issue features articles from Frontera's science users spanning the sciences from climate change to tornadoes and organic solar cells. We also include two computational science articles highlighting the tools and techniques that are needed to enable users running single jobs beyond 8,000 nodes.
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