Estimation of the solubility with cosolvent composition by combinated of the Williams–Amidon model with quasi virial coefficient

摘要

titleAbstract/titlepA new model that combined the Williams–Amidon model with quasi virial coefficient (WA‐QVC) was proposed. Compared with the log‐linear model, the modified Wilson model, and the Williams–Amidon model, the WA‐QVC model has the highest accuracy to correlate the solubility for cosolvent composition, iR/isup2/sup0.999. For lutelin, it can be seen that the order of iR/isup2/sup was WA‐QVCWAMWL‐L, while the order of iroot‐mean‐square deviation/i was WA‐QVCWAMWL‐L. Subsequently, the physical meaning of several model parameters of iB/isub1/sub, iX/isub1/sub, iB/isub2/sub, iB/isub3/sub, and iα/i were discussed and described by the Apelblat model, the exponential model, and the quadratic equation. In addition, the WA‐QVC model was tested and verified by solubility data of different solutes in different mixture with higher accuracy, indicating that the WA‐QVC model has great application prospect./p