Synthesis and Properties of Iron(II) and Copper(II) Coordination Compounds with 2,6-Bis1-(phenylimino)ethylpyridine

摘要

New iron(II) and copper(II) coordination compounds with 2,6-bis[1-(phenylimino)ethyl]pyridine (L-1), Fe(L-1)(2)SO4 center dot H2O, Fe(L-1)(2)(ClO4)(2), Cu(L-1)Cl-2, and Cu(L-1)(2)Br-2 center dot 2H(2)O, were synthesized. The compounds were identified and investigated using CHN analysis and electronic spectroscopy (diffuse reflectance spectroscopy), IR spectroscopy, XRD, and static magnetic susceptibility. Antiferromagnetic exchange interactions between paramagnetic centers are observed in all iron and copper complexes in the ranges 80-420 and 1.77-300 K, respectively. Evaluation of the cytotoxic activity of copper(II) complexes showed that the Cu(L-1)(2)Br-2 complex (IC50 26.7 mu mol/L) exhibits the highest activity against the human breast adenocarcinoma cell line (MCF-7).