Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues

摘要

ILCs are considered preformed effector cells. Gasteiger and colleagues report that ILC1s undergo effector differentiation after lineage commitment. Hobit+ ILC1s emerge as cKit+TCF-1hi cells that generate tissue-specific helper- and cytotoxic-like cells along a Hobit-dependent trajectory.